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primary human islets from seven normal and five t2d donors (appendix table )  (Prodo Labs)

 
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    Prodo Labs primary human islets from seven normal and five t2d donors (appendix table )
    A, B (A) Islet insulin content and (B) islet apoptosis of normal or <t>T2D</t> human islets with AAV transduction ( n = 8). C, D Representative immunostaining and quantification showing (C) insulin/Ki67 and (D) insulin/TUNEL signals in normal or T2D human islets with AAV transduction ( n = 5–6). Scale bar = 20 μm. E Protein expression of insulin and incretin signaling components in normal or T2D human islets with AAV transduction ( n = 4). F Phosphorylated and total Akt in human islets after 15‐min insulin (100 nM) stimulation ( n = 4). G, H Phosphorylated and total CREB in human islets after 15‐min (G) Exendin‐4 (10 nM) or (H) GIP (10 nM) stimulation ( n = 4). Data information: Each n represents an independent biological replicate (A–H). One‐way ANOVA (A–D). One‐way ANOVA and Kruskal–Wallis test (E). (F–H) Two‐way ANOVA. Data are means ± SEM. ns, nonsignificant. Source data are available online for this figure.
    Primary Human Islets From Seven Normal And Five T2d Donors (Appendix Table ), supplied by Prodo Labs, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/primary human islets from seven normal and five t2d donors (appendix table )/product/Prodo Labs
    Average 90 stars, based on 1 article reviews
    primary human islets from seven normal and five t2d donors (appendix table ) - by Bioz Stars, 2026-05
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    1) Product Images from "Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy"

    Article Title: Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy

    Journal: EMBO Molecular Medicine

    doi: 10.15252/emmm.202317928

    A, B (A) Islet insulin content and (B) islet apoptosis of normal or T2D human islets with AAV transduction ( n = 8). C, D Representative immunostaining and quantification showing (C) insulin/Ki67 and (D) insulin/TUNEL signals in normal or T2D human islets with AAV transduction ( n = 5–6). Scale bar = 20 μm. E Protein expression of insulin and incretin signaling components in normal or T2D human islets with AAV transduction ( n = 4). F Phosphorylated and total Akt in human islets after 15‐min insulin (100 nM) stimulation ( n = 4). G, H Phosphorylated and total CREB in human islets after 15‐min (G) Exendin‐4 (10 nM) or (H) GIP (10 nM) stimulation ( n = 4). Data information: Each n represents an independent biological replicate (A–H). One‐way ANOVA (A–D). One‐way ANOVA and Kruskal–Wallis test (E). (F–H) Two‐way ANOVA. Data are means ± SEM. ns, nonsignificant. Source data are available online for this figure.
    Figure Legend Snippet: A, B (A) Islet insulin content and (B) islet apoptosis of normal or T2D human islets with AAV transduction ( n = 8). C, D Representative immunostaining and quantification showing (C) insulin/Ki67 and (D) insulin/TUNEL signals in normal or T2D human islets with AAV transduction ( n = 5–6). Scale bar = 20 μm. E Protein expression of insulin and incretin signaling components in normal or T2D human islets with AAV transduction ( n = 4). F Phosphorylated and total Akt in human islets after 15‐min insulin (100 nM) stimulation ( n = 4). G, H Phosphorylated and total CREB in human islets after 15‐min (G) Exendin‐4 (10 nM) or (H) GIP (10 nM) stimulation ( n = 4). Data information: Each n represents an independent biological replicate (A–H). One‐way ANOVA (A–D). One‐way ANOVA and Kruskal–Wallis test (E). (F–H) Two‐way ANOVA. Data are means ± SEM. ns, nonsignificant. Source data are available online for this figure.

    Techniques Used: Transduction, Immunostaining, TUNEL Assay, Expressing

    A–C (A) Fasting blood glucose, (B) glucose tolerance, and (C) glucose profiles calculated as AUC of control or STZ‐treated mice transplanted with normal or T2D human islets ( n = 7–8). D Serum human insulin ( n = 7–8). E Representative immunostaining showing insulin/glucagon signal and ELISA measurement of human insulin content in human islet grafts ( n = 4–5). Scale bar = 100 μm. F Representative immunostaining and quantification showing insulin/TUNEL signal in human islet grafts ( n = 5). Scale bar = 100 μm. Data information: Each n represents the measurement of a sample from distinct mice (A–F). One‐way ANOVA (A–F). Data are means ± SEM. AUC, area under the curve; ns, nonsignificant. Source data are available online for this figure.
    Figure Legend Snippet: A–C (A) Fasting blood glucose, (B) glucose tolerance, and (C) glucose profiles calculated as AUC of control or STZ‐treated mice transplanted with normal or T2D human islets ( n = 7–8). D Serum human insulin ( n = 7–8). E Representative immunostaining showing insulin/glucagon signal and ELISA measurement of human insulin content in human islet grafts ( n = 4–5). Scale bar = 100 μm. F Representative immunostaining and quantification showing insulin/TUNEL signal in human islet grafts ( n = 5). Scale bar = 100 μm. Data information: Each n represents the measurement of a sample from distinct mice (A–F). One‐way ANOVA (A–F). Data are means ± SEM. AUC, area under the curve; ns, nonsignificant. Source data are available online for this figure.

    Techniques Used: Immunostaining, Enzyme-linked Immunosorbent Assay, TUNEL Assay



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    primary human islets from seven normal and five t2d donors (appendix table )  (Prodo Labs)
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    Prodo Labs primary human islets from seven normal and five t2d donors (appendix table )
    A, B (A) Islet insulin content and (B) islet apoptosis of normal or <t>T2D</t> human islets with AAV transduction ( n = 8). C, D Representative immunostaining and quantification showing (C) insulin/Ki67 and (D) insulin/TUNEL signals in normal or T2D human islets with AAV transduction ( n = 5–6). Scale bar = 20 μm. E Protein expression of insulin and incretin signaling components in normal or T2D human islets with AAV transduction ( n = 4). F Phosphorylated and total Akt in human islets after 15‐min insulin (100 nM) stimulation ( n = 4). G, H Phosphorylated and total CREB in human islets after 15‐min (G) Exendin‐4 (10 nM) or (H) GIP (10 nM) stimulation ( n = 4). Data information: Each n represents an independent biological replicate (A–H). One‐way ANOVA (A–D). One‐way ANOVA and Kruskal–Wallis test (E). (F–H) Two‐way ANOVA. Data are means ± SEM. ns, nonsignificant. Source data are available online for this figure.
    Primary Human Islets From Seven Normal And Five T2d Donors (Appendix Table ), supplied by Prodo Labs, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/primary human islets from seven normal and five t2d donors (appendix table )/product/Prodo Labs
    Average 90 stars, based on 1 article reviews
    primary human islets from seven normal and five t2d donors (appendix table ) - by Bioz Stars, 2026-05
    90/100 stars
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    A, B (A) Islet insulin content and (B) islet apoptosis of normal or T2D human islets with AAV transduction ( n = 8). C, D Representative immunostaining and quantification showing (C) insulin/Ki67 and (D) insulin/TUNEL signals in normal or T2D human islets with AAV transduction ( n = 5–6). Scale bar = 20 μm. E Protein expression of insulin and incretin signaling components in normal or T2D human islets with AAV transduction ( n = 4). F Phosphorylated and total Akt in human islets after 15‐min insulin (100 nM) stimulation ( n = 4). G, H Phosphorylated and total CREB in human islets after 15‐min (G) Exendin‐4 (10 nM) or (H) GIP (10 nM) stimulation ( n = 4). Data information: Each n represents an independent biological replicate (A–H). One‐way ANOVA (A–D). One‐way ANOVA and Kruskal–Wallis test (E). (F–H) Two‐way ANOVA. Data are means ± SEM. ns, nonsignificant. Source data are available online for this figure.

    Journal: EMBO Molecular Medicine

    Article Title: Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy

    doi: 10.15252/emmm.202317928

    Figure Lengend Snippet: A, B (A) Islet insulin content and (B) islet apoptosis of normal or T2D human islets with AAV transduction ( n = 8). C, D Representative immunostaining and quantification showing (C) insulin/Ki67 and (D) insulin/TUNEL signals in normal or T2D human islets with AAV transduction ( n = 5–6). Scale bar = 20 μm. E Protein expression of insulin and incretin signaling components in normal or T2D human islets with AAV transduction ( n = 4). F Phosphorylated and total Akt in human islets after 15‐min insulin (100 nM) stimulation ( n = 4). G, H Phosphorylated and total CREB in human islets after 15‐min (G) Exendin‐4 (10 nM) or (H) GIP (10 nM) stimulation ( n = 4). Data information: Each n represents an independent biological replicate (A–H). One‐way ANOVA (A–D). One‐way ANOVA and Kruskal–Wallis test (E). (F–H) Two‐way ANOVA. Data are means ± SEM. ns, nonsignificant. Source data are available online for this figure.

    Article Snippet: Primary human islets from seven normal and five T2D donors (Appendix Table ) were obtained from Prodo Laboratories, Inc. (Aliso Viejo, CA, USA).

    Techniques: Transduction, Immunostaining, TUNEL Assay, Expressing

    A–C (A) Fasting blood glucose, (B) glucose tolerance, and (C) glucose profiles calculated as AUC of control or STZ‐treated mice transplanted with normal or T2D human islets ( n = 7–8). D Serum human insulin ( n = 7–8). E Representative immunostaining showing insulin/glucagon signal and ELISA measurement of human insulin content in human islet grafts ( n = 4–5). Scale bar = 100 μm. F Representative immunostaining and quantification showing insulin/TUNEL signal in human islet grafts ( n = 5). Scale bar = 100 μm. Data information: Each n represents the measurement of a sample from distinct mice (A–F). One‐way ANOVA (A–F). Data are means ± SEM. AUC, area under the curve; ns, nonsignificant. Source data are available online for this figure.

    Journal: EMBO Molecular Medicine

    Article Title: Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy

    doi: 10.15252/emmm.202317928

    Figure Lengend Snippet: A–C (A) Fasting blood glucose, (B) glucose tolerance, and (C) glucose profiles calculated as AUC of control or STZ‐treated mice transplanted with normal or T2D human islets ( n = 7–8). D Serum human insulin ( n = 7–8). E Representative immunostaining showing insulin/glucagon signal and ELISA measurement of human insulin content in human islet grafts ( n = 4–5). Scale bar = 100 μm. F Representative immunostaining and quantification showing insulin/TUNEL signal in human islet grafts ( n = 5). Scale bar = 100 μm. Data information: Each n represents the measurement of a sample from distinct mice (A–F). One‐way ANOVA (A–F). Data are means ± SEM. AUC, area under the curve; ns, nonsignificant. Source data are available online for this figure.

    Article Snippet: Primary human islets from seven normal and five T2D donors (Appendix Table ) were obtained from Prodo Laboratories, Inc. (Aliso Viejo, CA, USA).

    Techniques: Immunostaining, Enzyme-linked Immunosorbent Assay, TUNEL Assay